Impact of <i>APOE4</i> Allele on Cell‐Cell Communication and α‐Synuclein Aggregation in Lewy Body Dementia: Insights from Spatial Transcriptomics
Our findings indicate that impaired cell-cell communication, such as microglia-mediated immune responses around LB regions, may be associated with the increased risk presented by the APOE4 allele in LBD brains.
Authors
- Yuanhang Liu (ORCID: https://orcid.org/0000-0002-0147-8394)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Shunsuke Koga (ORCID: https://orcid.org/0000-0001-8868-9700)
- Guojun Bu (ORCID: https://orcid.org/0000-0003-3491-1016)
- Zonghua Li (ORCID: https://orcid.org/0000-0001-5242-9608)
- Yunjung Jin
- Na Zhao (ORCID: https://orcid.org/0000-0001-8648-9422)
- Alexander Q. Wixom
- Hiroaki Sekiya (ORCID: https://orcid.org/0000-0001-9683-5966)
- Hannah Santhakumar (ORCID: https://orcid.org/0009-0008-4851-4437)
Institutions
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092756
- Citations
- 1
- Primary Topic
- Biotin and Related Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.33