Evaluating the association between <i>APOE</i> genotypes and cognitive resilience in SuperAgers
Within our large, harmonized cohort, larger proportions of SuperAgers had APOE-ε2 alleles and smaller proportions had APOE-ε4 alleles than AD cases across both NHW and NHB participants. Crucially, higher proportions of NHW SuperAgers had APOE-ε2 alleles than younger controls (ages<80) and lower proportions had APOE-ε4 alleles than all controls including age-matched controls (ages 80+). This work provides the strongest evidence to date that APOE is associated with SuperAging. APOE-ε2 did not differentiate NHB SuperAgers from controls nor APOE-ε4 from other oldest-old adults in present analyses. Future work will extend to whole genome analysis to identify novel genomic drivers of SuperAging.
Authors
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Weixin Wang (ORCID: https://orcid.org/0000-0002-2765-2629)
- Jonathan L. Haines (ORCID: https://orcid.org/0000-0002-4351-4728)
- Michael L. Lee (ORCID: https://orcid.org/0000-0002-3112-1214)
- Emily H. Trittschuh (ORCID: https://orcid.org/0000-0003-0557-1542)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0003-0756-5007)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Lisa L. Barnes (ORCID: https://orcid.org/0000-0002-0072-9817)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- C. Dirk Keene (ORCID: https://orcid.org/0000-0002-5291-1469)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Carlos C Cruchaga (ORCID: https://orcid.org/0000-0002-0276-2899)
- David Bennett (ORCID: https://orcid.org/0000-0001-5354-152X)
- Corinne D. Engelman (ORCID: https://orcid.org/0000-0003-4750-5607)
- Leslie S. Gaynor (ORCID: https://orcid.org/0000-0003-1121-4365)
- Paul K. Crane (ORCID: https://orcid.org/0000-0003-4278-7465)
- Adam C. Naj (ORCID: https://orcid.org/0000-0002-9621-2942)
- Shubhabrata Mukherjee (ORCID: https://orcid.org/0000-0003-2522-2884)
- Walter A. Kukull (ORCID: https://orcid.org/0000-0001-8761-9014)
- Angela Lee Jefferson (ORCID: https://orcid.org/0000-0002-8245-0587)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Phoebe Scollard
- Eden R. Martin (ORCID: https://orcid.org/0000-0002-4035-9152)
- Brian W. Kunkle (ORCID: https://orcid.org/0000-0002-9515-5157)
- Badri Narayan Vardarajan (ORCID: https://orcid.org/0000-0002-5560-4085)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Alaina Durant
- Paul M. Thompson (ORCID: https://orcid.org/0000-0002-4720-8867)
- Seo‐Eun Choi (ORCID: https://orcid.org/0000-0002-2163-688X)
- Jason J. Hassenstab (ORCID: https://orcid.org/0000-0002-7802-3371)
- Katherine A. Gifford (ORCID: https://orcid.org/0000-0001-6232-9408)
- Sterling C. Johnson
- Richard Mayeux
- Marilyn S. Albert
- Margaret A Pericak‐Vance
Institutions
- Boston University (US)
- University of Southern California (US)
- Rush University Medical Center (US)
- NewYork–Presbyterian Hospital (US)
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- University of Miami (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- New York Hospital Queens (US)
- VA Puget Sound Health Care System (US)
- Dr. John T. Macdonald Foundation (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093260
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00