Sex dependent pleiotropic effects of <i>Apolipoprotein (ApoE) 4</i> on executive function in mice and humans
Taken together, these results support the ApoE4 antagonistic pleiotropy hypothesis, whereby ApoE4 carriership confers greater attentional performance early in life in both female humans and mice. These new mouse models, in combination with fully translatable touchscreen tests of cognition, can be used to explore potential mechanisms by which ApoE4 can affect different aspects of brain function across the life span.
Authors
- Mark Longmuir
- Daniel Palmer (ORCID: https://orcid.org/0000-0002-7954-9332)
- Vânia F. Prado (ORCID: https://orcid.org/0000-0003-4994-6393)
- Marco A. M. Prado (ORCID: https://orcid.org/0000-0002-3028-5778)
- Lisa M. Saksida (ORCID: https://orcid.org/0000-0002-8416-8171)
- Timothy J. Bussey (ORCID: https://orcid.org/0000-0001-7518-4041)
- Taylor W. Schmitz (ORCID: https://orcid.org/0000-0003-0585-7524)
- Kate M. Onuska (ORCID: https://orcid.org/0000-0001-6150-4403)
- R. Nathan Spreng (ORCID: https://orcid.org/0000-0003-1530-8916)
- Aya Arrar
Institutions
- Western University (CA)
- Montreal Neurological Institute and Hospital (CA)
- Lawson Health Research Institute (CA)
- Douglas Mental Health University Institute (CA)
- Alzheimer Society of Canada (CA)
- Robarts Clinical Trials (CA)
- McGill Genome Centre (CA)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092572
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00