Advanced modeling of bioenergetics in the mitochondrial electron transport chain with emphasis on complex IV
Our refined mathematical model successfully simulates mitochondrial bioenergetics, emphasizing Complex IV dynamics. Validated against experimental data, the model accurately reproduces bioenergetic activities and demonstrates the potential for studying mitochondrial dysfunction and neurodegenerative diseases. The integration of inhibiting and uncoupling reagents, along with the user-friendly GUI, enhances accessibility and usability. Our research contributes to advancing the medical understanding, emphasizing the role of computational models in unraveling mitochondrial complexities in neurological disorders.
Authors
- Jelena Djordjevic (ORCID: https://orcid.org/0000-0001-9769-6857)
- Chris Cadonic (ORCID: https://orcid.org/0000-0001-9074-5871)
- Paul Fernyhough (ORCID: https://orcid.org/0000-0002-9507-1201)
- Ella A. Thomson (ORCID: https://orcid.org/0000-0002-3294-3092)
- Taravat Ghafourian (ORCID: https://orcid.org/0000-0002-3136-3117)
- Danielle McAllister
- Jason Fiege
- Benedict C. Albensi (ORCID: https://orcid.org/0000-0002-7884-9261)
- Subir Roy Chowdhury (ORCID: https://orcid.org/0009-0001-4991-6795)
- Stéphanie Portet (ORCID: https://orcid.org/0000-0002-8802-8184)
- Marzieh Eini Keleshteri (ORCID: https://orcid.org/0000-0002-2623-8522)
- Wanda M. Snow
Institutions
- Nova Southeastern University (US)
- St. Boniface Hospital (CA)
- University of Manitoba (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090369
- Citations
- 1
- Primary Topic
- ATP Synthase and ATPases Research
- Type
- article
- Field-Weighted Citation Impact
- 0.23