Astrocytic induction of triglyceride lipolysis in AD‐associated pathology and neuroinflammation
Our findings suggest that Aβ pathology and neuroinflammatory factors cause astrocytic triglyceride lipolysis, a process that liberates fatty acids to be utilized for various potentially pathogenic cascades in disease. We conclude that amyloid pathology and neuroimmune factors converge to alter astrocytic lipid-related gene transcription and lipid-based signaling.
Authors
- Daniel Barnett (ORCID: https://orcid.org/0000-0002-1340-4413)
- Adam L. Orr (ORCID: https://orcid.org/0000-0003-0338-7709)
- Till S. Zimmer (ORCID: https://orcid.org/0000-0002-6869-3697)
- Anna G. Orr (ORCID: https://orcid.org/0000-0002-4036-4277)
Institutions
- Cornell University (US)
- MIND Research Institute (US)
- Tri-Institutional PhD Program in Chemical Biology (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093056
- Primary Topic
- Lipid metabolism and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00