Microglial priming induced by high‐fat diet consumption causes complement C1q‐mediated synaptic elimination leading to cognitive decline and depressive‐like behavior
Our findings suggest that only 4-week HFD consumption effectively primed microglia to a similar extent as primed with a single dose of LPS injection, leading to excessive synaptic engulfment, as well as cognitive decline and depressive-like behavior in the second LPS stimulation after 4-week of HFD withdrawal period.
Authors
- Nipon Chattipakorn (ORCID: https://orcid.org/0000-0003-3026-718X)
- Wasana Pratchayasakul (ORCID: https://orcid.org/0000-0003-3970-4323)
- Titikorn Chunchai (ORCID: https://orcid.org/0000-0003-4405-1208)
- Busarin Arunsak (ORCID: https://orcid.org/0000-0002-5120-288X)
- Nattayaporn Apaijai (ORCID: https://orcid.org/0000-0002-1265-5210)
- Hiranya Pintana
- Patcharapong Pantiya (ORCID: https://orcid.org/0000-0002-2181-7197)
- Thirathada Chinchapo
- Nipon Chattipakorn
- Suriphan Donchada
Institutions
- Chiang Mai University (TH)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085030
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00