Trans‐ancestry GWAS for Alzheimer’s Disease Reveals a Novel Locus interacting with <i>APOE</i>*4

We show the relevance of expanding beyond non-Hispanic white samples to identify genetic risk variants that may modulate the effect of APOE*4 on AD risk, identifying a risk locus with substantially elevated frequencies in African compared to European ancestry. The locus harbored APOB, a ligand for the LDL receptor, regulator of plasma cholesterol levels, and known to have mutations in its regulatory region that cause hypobetalipoproteinemia and hypercholesterolemia. Ongoing work is exploring replication and computational functional genomics follow-up work.