Nonfibrillar Dutch mutant amyloid beta (Aß) aggregates (oligomers) are associated with aging‐related synaptic dysfunction
The profound learning behavior deficits in Dutch mice are associated with presynaptic functional deficits and mitochondrial abnormalities in excitatory neurons of the hippocampus. Nonfibrillar oAβ deposits were revealed by co-localization of A11 immunoreactivity with FITC-CP-2 microscopy. Mice accumulating only oAβ may be especially useful for further characterization of the oligomer-specific cyclic azaglycine PET tracer Lys (<sup>64</sup>Cu/NOTA)<sup>1</sup>]-CP-7 that shows robust PET signal from 44-day-old presymptomatic 5xFAD mice [Habashi, M. et al. Proc. Natl. Acad. Sci. U.S.A. 2022].
Authors
- Francesca Garretti (ORCID: https://orcid.org/0000-0002-6609-8034)
- Kuldeep Tripathi (ORCID: https://orcid.org/0000-0003-4850-0218)
- Brigitte Guérin (ORCID: https://orcid.org/0000-0002-0319-4512)
- Lars Lannfelt (ORCID: https://orcid.org/0000-0001-9839-659X)
- David K. Lerner (ORCID: https://orcid.org/0000-0002-0431-2920)
- Linda Söderberg (ORCID: https://orcid.org/0009-0003-6075-4568)
- Elentina K. Argyrousi (ORCID: https://orcid.org/0000-0003-3716-807X)
- Efrat Levy (ORCID: https://orcid.org/0000-0001-6890-6763)
- Ottavio Arancio (ORCID: https://orcid.org/0000-0001-6335-164X)
- William D. Lubell (ORCID: https://orcid.org/0000-0002-3080-2712)
- Shai Rahimipour (ORCID: https://orcid.org/0000-0002-3210-1645)
- Dara L. Dickstein (ORCID: https://orcid.org/0009-0002-4142-8807)
- Michelle E. Ehrlich (ORCID: https://orcid.org/0000-0001-9397-686X)
- Ronan Talty (ORCID: https://orcid.org/0000-0002-8742-3799)
- Merina Varghese (ORCID: https://orcid.org/0000-0002-1517-3903)
- Charles Glabe (ORCID: https://orcid.org/0000-0002-0599-0184)
- Erin Bresnahan
- Emilie L. Castranio (ORCID: https://orcid.org/0000-0001-6817-7388)
- Minghui Wang (ORCID: https://orcid.org/0000-0001-9171-4962)
- Bin Zhang (ORCID: https://orcid.org/0000-0002-9549-5653)
- Hong Zhang (ORCID: https://orcid.org/0000-0002-4084-5150)
- Jonathan Van de Loo (ORCID: https://orcid.org/0009-0003-5275-9246)
- Sam Gandy (ORCID: https://orcid.org/0000-0001-6455-4721)
Institutions
- Nathan Kline Institute for Psychiatric Research (US)
- Université de Sherbrooke (CA)
- Bar-Ilan University (IL)
- Uniformed Services University of the Health Sciences (US)
- University of California, Irvine (US)
- Center for Information Technology (US)
- Yale University (US)
- BioArctic Neuroscience (Sweden) (SE)
- New York University (US)
- Université de Montréal (CA)
- Columbia University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.084937
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00