Using three‐dimensional histology to visualize vascular tau accumulation in Alzheimer’s disease
These data indicate that tau accumulates on blood vessels in the Alzheimer's disease brain to a greater extent than previously appreciated. Further, they highlight the utility of three-dimensional histology methods for visualizing and quantifying novel relationships between features in the brain.
Authors
- Theodore J. Zwang (ORCID: https://orcid.org/0000-0002-6815-4482)
- Benjamin Woost
- Zachary Hoglund (ORCID: https://orcid.org/0009-0008-6490-9957)
- Eric del Sastre (ORCID: https://orcid.org/0000-0003-0772-2279)
- Nancy E. Ruiz‐Uribe (ORCID: https://orcid.org/0000-0003-0671-9617)
- Rachel E. Bennett (ORCID: https://orcid.org/0000-0001-9640-0575)
- Joshua Bailey
Institutions
- Northeastern University (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085808
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00