Presynaptic toxicity of the AD susceptibility gene BIN1
Our results suggest that BIN1 has an isoform-specific, deleterious effect on synaptic integrity when expressed in the presynaptic terminal. This effect could contribute to the synaptic loss observed early in AD.
Authors
- Jean‐Charles Lambert (ORCID: https://orcid.org/0000-0003-0829-7817)
- Alejandra Freire‐Regatillo (ORCID: https://orcid.org/0000-0002-8202-5871)
- Xavier Hermant
- Nicolas Barois (ORCID: https://orcid.org/0000-0002-5057-1931)
- Philippe Amouyel (ORCID: https://orcid.org/0000-0001-9088-234X)
- Patrik Verstreken (ORCID: https://orcid.org/0000-0002-5073-5393)
- Erwan Lambert (ORCID: https://orcid.org/0000-0002-4994-9212)
- Pierre Dourlen (ORCID: https://orcid.org/0000-0002-3562-1080)
- Devrim Kilinc (ORCID: https://orcid.org/0000-0003-3321-5203)
- Frank Lafont (ORCID: https://orcid.org/0000-0001-8668-2580)
- Carla Gelle
- Vincent Leclerc (ORCID: https://orcid.org/0000-0002-9338-0000)
- Tommy Malfoi
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Lille (FR)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088949
- Primary Topic
- Attention Deficit Hyperactivity Disorder
- Type
- article
- Field-Weighted Citation Impact
- 0.00