A polygenic risk score contributes to identifying individuals with the potential for cognitive function improvement
While we have successfully developed a Japanese PRS with high predictive ability, it is important to note that our dataset is limited and relatively small. To achieve an accurate AD PRS for the Japanese population, further validation studies are necessary, involving a larger dataset or conducting a meta-analysis with another Japanese cohort. Additionally, our study highlights the potential utility of the PRS in screening subjects for cognitive improvement, especially for individuals with high PRS in the young-old group.
Authors
- Kosuke Fujita (ORCID: https://orcid.org/0000-0001-7277-5209)
- Daichi Shigemizu (ORCID: https://orcid.org/0000-0002-4412-0552)
- Kouichi Ozaki (ORCID: https://orcid.org/0000-0003-0028-1570)
- Hidenori Arai (ORCID: https://orcid.org/0000-0001-6747-8680)
- Takashi Sakurai (ORCID: https://orcid.org/0000-0002-2369-3095)
- Shumpei Niida (ORCID: https://orcid.org/0000-0002-6192-8035)
Institutions
- Hiroshima University (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- National Center for Geriatrics and Gerontology (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086348
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00