Identifying genetic risk factors driving cerebral amyloid angiopathy using novel mouse models
Robust BXW.APP/PS1 CAA suggests heterozygous loci promote CAA. F2 CAA variability suggests CAA-susceptibility loci are likely mappable. F2 SNP analysis and R/qtl2 software is being employed to identify candidate loci corresponding with CAA. Furthermore, BXW.APP/PS1 is a novel CAA model to study the therapeutic potential of pTIE2 enhancement. To this end, BXW.Angpt2<sup>±</sup>APP/PS1 and BXW.Ptprb<sup>+/D57N</sup>APP/PS1 mice are aging and will be evaluated for pTIE2 elevation and CAA attenuation.
Authors
- Gareth R. Howell (ORCID: https://orcid.org/0000-0003-0565-6474)
- Kristen D. Onos (ORCID: https://orcid.org/0000-0001-6443-6557)
- Cory A. Diemler (ORCID: https://orcid.org/0000-0003-0050-2716)
- Olivia J. Marola (ORCID: https://orcid.org/0000-0002-0078-6088)
- Michael Sasner (ORCID: https://orcid.org/0000-0002-6612-6111)
- Kelly J. Keezer
Institutions
- Jackson Laboratory (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091446
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00