Circulating microRNAs related to cognitive performance in the general population
We identified microRNA clusters and individual microRNAs that were related to different cognitive functions. Some of these microRNAs were also related to cortical thickness, suggesting that part of their relation with cognition is mediated through alterations of brain structure. The identified microRNAs regulated genes related to brain homeostasis and development. Our results contribute to a better understanding of brain epigenetics and provide potential molecular targets for the detection, prevention or treatment of cognitive dysfunction.
Authors
- André Fischer (ORCID: https://orcid.org/0000-0001-8546-1161)
- N. Ahmad Aziz (ORCID: https://orcid.org/0000-0001-6184-458X)
- D. Krüger (ORCID: https://orcid.org/0000-0003-1950-9547)
- Monique M.B. Breteler (ORCID: https://orcid.org/0000-0002-0626-9305)
- Valentina Talevi (ORCID: https://orcid.org/0000-0003-4418-7439)
- Konstantinos Melas (ORCID: https://orcid.org/0009-0000-5206-5322)
- Tonatiuh Peña
Institutions
- University of Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- Institut für Medizinische Biometrie, Informatik und Epidemiologie (DE)
- Universitätsmedizin Göttingen (DE)
- Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103 (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.083648
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00