Pathological patterns of TDP‐43 in LATE, Alzheimer’s Disease and FTLD‐TDP
These results suggest that TDP-43 assumes distinct patterns of immunoreactivity in dementia, especially in the hippocampus. LATE and FTLD-TDP cases showed a similar, but non-identical patterns of TDP-43 immunoreactive species, patterns which were different in turn from LATE-NC in ADNC. These data may also support the concept of LATE as a separate disease with high burdens of different TDP-43 species restricted to the limbic system in the absence of moderate-high ADNC.
Authors
- Klara Gawor (ORCID: https://orcid.org/0000-0001-7571-5420)
- Peter T. Nelson (ORCID: https://orcid.org/0000-0002-6161-1265)
- Dietmar Rudolf Thal (ORCID: https://orcid.org/0000-0002-1036-1075)
- Rik R. Vandenberghe (ORCID: https://orcid.org/0000-0001-6237-2502)
- Sandra O. Tomé (ORCID: https://orcid.org/0000-0001-5253-0730)
Institutions
- University of Kentucky (US)
- Universitair Ziekenhuis Leuven (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091232
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00