Using disease‐selective cell lines to investigate tau strain biology
We have developed two cell lines that selectively replicate tau prions isolated from CBD patient samples. To our knowledge, this is the first assay capable of differentiating between two different 4R tau prion strains, representing a significant advancement towards the development of disease-specific diagnostic tools.
Authors
- Sara A. M. Holec (ORCID: https://orcid.org/0000-0003-0800-1115)
- Christine Brown
- Amanda L. Woerman (ORCID: https://orcid.org/0000-0003-4029-1968)
- Matthew P. Frost
Institutions
- University of Connecticut (US)
- University of Massachusetts Amherst (US)
- Colorado State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089601
- Primary Topic
- Mechanisms of cancer metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00