Spatial transcriptomics reveals neuroimmune mechanisms of Aβ clearance in immunized Alzheimer’s disease patients
Altogether, our data uncover immediate and lasting neuroimmune responses in the AD brain induced by active and passive Aβ vaccination.
Authors
- Rudolph J. Castellani (ORCID: https://orcid.org/0000-0002-5414-3184)
- Ann Forsyth (ORCID: https://orcid.org/0000-0002-8400-6842)
- Delphine Boche (ORCID: https://orcid.org/0000-0002-5884-130X)
- Jeanette Norman
- Talia Krainc (ORCID: https://orcid.org/0000-0001-5665-241X)
- Thomas J. Watson (ORCID: https://orcid.org/0000-0002-3282-494X)
- Nate Shepard
- Benney MR Argue (ORCID: https://orcid.org/0009-0009-9799-901X)
- David Gate (ORCID: https://orcid.org/0000-0003-0481-9657)
- Pouya Jamshidi (ORCID: https://orcid.org/0000-0002-2038-8589)
- Brooke Simonton (ORCID: https://orcid.org/0000-0002-1366-1268)
- James A. R. Nicoll (ORCID: https://orcid.org/0000-0002-9444-7246)
- Lynn van Olst (ORCID: https://orcid.org/0000-0001-7569-0470)
- Ziyang Zhang (ORCID: https://orcid.org/0000-0001-5870-704X)
- Hang Xu (ORCID: https://orcid.org/0000-0002-8336-4445)
- Mengwei Li (ORCID: https://orcid.org/0000-0001-6163-2827)
- Jinmiao Chen (ORCID: https://orcid.org/0000-0001-7547-6423)
- Alex Edwards (ORCID: https://orcid.org/0009-0000-6518-5374)
Institutions
- Northwestern University (US)
- National University of Singapore (SG)
- Singapore Immunology Network (SG)
- University Hospital Southampton NHS Foundation Trust (GB)
- University of Southampton (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088081
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00