Leveraging dynamic enhancer landscapes to decode microglia phenotypes in Alzheimer’s disease
These studies indicate that the response to amyloid involves many transcription factors, nominates specific factors for further study, and reinforces the value of engrafting human microglia into disease models as a means of investigating the impact of human-specific non coding regulatory elements.
Authors
- Christopher K. Glass (ORCID: https://orcid.org/0000-0003-4344-3592)
Institutions
- University of California San Diego (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090381
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00