Deep Brain Stimulation of the Medial Septum Improves Okadaic Acid‐Induced Impairment of Spatial Working Memory and Restores the Cholinergic Activity in the Hippocampus

we suggest that the enhancement of working memory function may be associated with an increase in hippocampal neurogenesis and recovery of the AChE immune-stained cells numbers in the hippocampus induced by MS DBS in a rat model of AD. These results allow us to identify the medial septum as one of the stimulation sites for improving memory function.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.087892
Primary Topic
Memory and Neural Mechanisms
Type
article
Field-Weighted Citation Impact
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article

Deep Brain Stimulation of the Medial Septum Improves Okadaic Acid‐Induced Impairment of Spatial Working Memory and Restores the Cholinergic Activity in the Hippocampus

MARIAM CHIGHLADZE, M. Dashniani, M. Burjanadze, Khatuna Rusadze et al.
Alzheimer s & Dementia
Memory and Neural Mechanisms
article

Deep Brain Stimulation of the Medial Septum Improves Okadaic Acid‐Induced Impairment of Spatial Working Memory and Restores the Cholinergic Activity in the Hippocampus

MARIAM CHIGHLADZE, M. Dashniani, M. Burjanadze, Khatuna Rusadze, Lali Kruashvili
article en

Abstract

we suggest that the enhancement of working memory function may be associated with an increase in hippocampal neurogenesis and recovery of the AChE immune-stained cells numbers in the hippocampus induced by MS DBS in a rat model of AD. These results allow us to identify the medial septum as one of the stimulation sites for improving memory function.

Alzheimer s & DementiaVol. 20(S1)
Tbilisi State University (GE)
Openalex Percentile: Top 74%
Memory and Neural Mechanisms
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