Amyloid β and cardiovascular risk factors promote endothelial cell apoptotic and mitochondrial stress, blood‐brain barrier dysfunction and angiogenesis impairment

This data highlights new and specific molecular mechanisms that drive endothelial and BBB pathology in AD/CAA in the presence or absence of a comorbid cerebrovascular condition such as Hhcy. Moreover, we discovered a new potential therapeutic target, carbonic anhydrase, whose inhibition can revert the cerebrovascular effects of Aβ in vitro and in vivo.