Whole blood DNA methylation profiles of Alzheimer’s disease differ across ancestrally diverse populations
While these results are preliminary, and expansion of the dataset may reveal convergence of methylation patterns across ancestral populations, our analyses suggest the possibility of ancestry specific whole blood DNA methylation patterns as signatures of AD pathogenesis. Ultimately, combining these methylation profiles with existing genomic and transcriptomic data may reveal distinct genes but similar underlying pathological processes contributing to AD across individuals of diverse ancestries.
Authors
- Mario Cornejo‐Olivas (ORCID: https://orcid.org/0000-0001-6313-5680)
- Tianjie Gu
- Gary W. Beecham (ORCID: https://orcid.org/0000-0002-7061-6332)
- Maryenela Illanes‐Manrique (ORCID: https://orcid.org/0000-0002-3098-0981)
- Patrice L. Whitehead
- Goldie S. Byrd (ORCID: https://orcid.org/0000-0003-1057-0261)
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Jeffery M. Vance (ORCID: https://orcid.org/0000-0003-3815-8199)
- Kara L. Hamilton‐Nelson (ORCID: https://orcid.org/0000-0003-3748-7193)
- Concepcion Silva‐Vergara
- Briseida E. Feliciano‐Astacio (ORCID: https://orcid.org/0000-0003-4747-8928)
- Takiyah D. Starks (ORCID: https://orcid.org/0000-0001-7267-3480)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- Jóse Javier Sánchez (ORCID: https://orcid.org/0000-0002-6638-177X)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Makaela Mews (ORCID: https://orcid.org/0009-0006-6416-7581)
- Lissette Gomez
- Larry D. Adams
- Jonathan L. Haines
- Margaret A Pericak‐Vance
Institutions
- University of Miami (US)
- Central University of the Caribbean (PR)
- Universidad Científica del Sur (PE)
- Dr. John T. Macdonald Foundation (US)
- Instituto Nacional de Ciencias Neurológicas
- Wake Forest University (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092713
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00