Amygdala‐predominant α‐synuclein pathology accelerates CA1 neuron loss in Alzheimer’s disease
Our findings indicate that the amygdala-specific αSyn pattern, but not the rostro-caudal one, may indirectly contribute to hippocampal neurodegeneration by enhancing the aggregation and toxicity of TDP-43 and pTau. Furthermore, our study reveals differences in neuropathological characteristics between AD patients with two spreading patterns. These findings underscore the significance of identifying co-morbid pathologies in AD patients and the necessity for further research on distinct αSyn subtypes.
Authors
- Alicja Ronisz (ORCID: https://orcid.org/0000-0002-4310-0445)
- Philip Van Damme (ORCID: https://orcid.org/0000-0002-4010-2357)
- Klara Gawor (ORCID: https://orcid.org/0000-0001-7571-5420)
- Dietmar Rudolf Thal (ORCID: https://orcid.org/0000-0002-1036-1075)
- Simona Ospitalieri
- Markus Otto (ORCID: https://orcid.org/0000-0003-4273-4267)
- Rik R. Vandenberghe (ORCID: https://orcid.org/0000-0001-6237-2502)
- Sandra O. Tomé (ORCID: https://orcid.org/0000-0001-5253-0730)
- Mathieu Vandenbulcke (ORCID: https://orcid.org/0000-0001-9765-1499)
- Matthew B. Blaschko (ORCID: https://orcid.org/0000-0002-2640-181X)
- Christine A. F. Von Arnim (ORCID: https://orcid.org/0000-0002-8614-2223)
Institutions
- Universitair Ziekenhuis Leuven (BE)
- Universitätsmedizin Göttingen (DE)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- University Hospital Ulm (DE)
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086519
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00