Targeting and reducing neuronal ceramide overaccumulation in 5xFAD mice improves AD pathologies and cognitive function
Pharmaceutical inhibition of ceramide synthesis improved cognitive outcomes and reduced AD pathologies in 5xFAD mice. Reducing ceramides specifically in neurons in 5xFAD mice eliminated gliosis and improved cognitive function.
Authors
- Scott A. Summers (ORCID: https://orcid.org/0000-0002-4919-0592)
- Joseph L. Wilkerson (ORCID: https://orcid.org/0000-0003-4683-7589)
- William L. Holland (ORCID: https://orcid.org/0000-0001-9950-1435)
- Amandine Chaix (ORCID: https://orcid.org/0000-0001-7007-197X)
Institutions
- University of Utah (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093451
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00