ZNF653 transcription factor activity is associated with FDG‐PET changes in AD brain‐vulnerable regions
We identified the activity of the ZNF653 regulatory unit associated with [18 F]FDG-PET metabolism in the brain of AD individuals. Furthermore, ZNF653 activity could be modulating metabolic and protein kinase activity-related genes, highlighting a potential role of this TF in AD.
Authors
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- João Pedro Ferrari‐Souza (ORCID: https://orcid.org/0000-0003-2183-1551)
- Guilherme Povala (ORCID: https://orcid.org/0000-0002-2023-6569)
- Eduardo Rigon Zimmer (ORCID: https://orcid.org/0000-0002-5349-0053)
- Pâmela C.L. Ferreira (ORCID: https://orcid.org/0000-0003-2134-9829)
- Bruno Zatt (ORCID: https://orcid.org/0000-0002-8045-957X)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Marco De Bastiani (ORCID: https://orcid.org/0000-0002-6212-1858)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Pelotas (BR)
- University of Pittsburgh (US)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.084700
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00