Toxic Interplay Between Small Dipeptide Protein Repeats and Tau in Tauopathies

Many studies have investigated the toxicity of small protein repeats, however, the role of DPR oligomers in inducing tau aggregation is still unclear. Thus, the ability to understand the toxic interplay between small peptide repeats and tau oligomers has great potential to further the understanding of tau progression and aid in the development of targeted therapeutics.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.093234
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Toxic Interplay Between Small Dipeptide Protein Repeats and Tau in Tauopathies

Rakez Kayed, Nemil Bhatt, Cynthia Jerez, Nikita Shchankin et al.
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

Toxic Interplay Between Small Dipeptide Protein Repeats and Tau in Tauopathies

Rakez Kayed, Nemil Bhatt, Cynthia Jerez, Nikita Shchankin, Nicha Puangmalai
article en

Abstract

Many studies have investigated the toxicity of small protein repeats, however, the role of DPR oligomers in inducing tau aggregation is still unclear. Thus, the ability to understand the toxic interplay between small peptide repeats and tau oligomers has great potential to further the understanding of tau progression and aid in the development of targeted therapeutics.

Alzheimer s & DementiaVol. 20(S1)
The University of Texas Medical Branch at Galveston (US)
Openalex Percentile: Top 65%
Alzheimer's disease research and treatments
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