X Ray Absorption Near Edge Spectroscopy (XANES) Shows Abnormal Iron Oxidation State in Alzheimer’s Hippocampi
We found increased Fe<sup>2+</sup> in thawed AD hippocampi compared to controls. Additionally, the thawing of frozen iron deposits resulted in a decrease of measured Fe<sup>2+</sup>. These findings may suggest actual differences are even higher between iron oxidation state in AD hippocampi versus controls.
Authors
- Michael Zeineh (ORCID: https://orcid.org/0000-0002-6940-9096)
- Marios Georgiadis (ORCID: https://orcid.org/0000-0003-0733-4559)
- Jeffrey Nirschl (ORCID: https://orcid.org/0000-0001-6857-341X)
- Samuel M. Webb (ORCID: https://orcid.org/0000-0003-1188-0464)
- Phillip DiGiacomo (ORCID: https://orcid.org/0000-0002-2441-4086)
- Nicholas P. Edwards (ORCID: https://orcid.org/0000-0002-3760-4225)
- Dean Tran (ORCID: https://orcid.org/0009-0006-5575-6464)
- Sharon Bone (ORCID: https://orcid.org/0000-0002-7521-9627)
Institutions
- SLAC National Accelerator Laboratory (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088089
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00