Diverse genomic alterations in single neurons after chronic brain trauma
Our results suggest that neurons in CTE brain are exposed to stereotyped mutational processes, and that these processes are shared between AD and CTE suggesting potentially shared pathogenic mechanisms. Furthermore, the absence of similar changes in RHI neurons without CTE suggests that the development of CTE entails a mechanism beyond that caused by RHI alone.
Authors
- Michael B. Miller (ORCID: https://orcid.org/0000-0002-6205-3314)
- Ann C. McKee (ORCID: https://orcid.org/0000-0003-2961-7488)
- August Yue Huang (ORCID: https://orcid.org/0000-0002-0416-2854)
- Eunjung Alice Lee (ORCID: https://orcid.org/0000-0002-6574-9261)
- Guanlan Dong (ORCID: https://orcid.org/0000-0002-4747-6036)
- Chanthia Ma
- Gannon A. McDonough (ORCID: https://orcid.org/0009-0002-8420-9970)
- Christopher A. Walsh
- Shulin Mao (ORCID: https://orcid.org/0000-0003-2916-6701)
- S. T. Naik
Institutions
- Boston University (US)
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Harvard University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091891
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00