Aberrant XIST beyond the inactivated X chromosome modulates the intracellular dysregulation in Alzheimer’s disease
This study reports the presence of XIST in cytoplasm in AD for the first time and sheds light on its downstream mechanisms mediated by this aberrant translocation. Studying XIST from the context of AD further allows us to establish the role of this imprinted lncRNA on the gender specific prevalence of AD.
Authors
- Debashis Mukhopadhyay (ORCID: https://orcid.org/0000-0002-4516-2260)
- Somenath Sen (ORCID: https://orcid.org/0009-0006-5001-2407)
Institutions
- Saha Institute of Nuclear Physics (IN)
- Homi Bhabha National Institute (IN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087394
- Primary Topic
- 14-3-3 protein interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00