Effects of Chronic Binge Alcohol Consumption on Alzheimer’s Disease Neuropathogenesis in 3xTg‐AD mice
Results indicate that 3xTg mice are more sensitive to EtOH-mediated effects on neurodegeneration and memory impairment than nonTg controls. There was also significant EtOH-induced dysregulation of AD-related processes in the mid-brain of 3xTg mice, a region affected early by AD neuropathology. Together, these data show that chronic mid-life EtOH binging accelerates early AD neuropathology in 3xTg mice.
Authors
- Smita S. Ghare (ORCID: https://orcid.org/0009-0005-9627-4843)
- Aakarsha V. Rao (ORCID: https://orcid.org/0009-0001-7149-2562)
- Craig J. McClain (ORCID: https://orcid.org/0000-0002-7219-8939)
- Julia H. Chariker (ORCID: https://orcid.org/0000-0001-6805-7220)
- Shirish Barve (ORCID: https://orcid.org/0009-0008-7833-527X)
- Sreelatha Reddy
- Eric C. Rouchka (ORCID: https://orcid.org/0000-0003-3487-6572)
- Paula M. Chilton (ORCID: https://orcid.org/0000-0002-8749-0975)
- Leila Gobejishvili (ORCID: https://orcid.org/0000-0001-8912-1834)
- Lucy Sloan (ORCID: https://orcid.org/0000-0002-2778-7224)
- Jiyeon Lee (ORCID: https://orcid.org/0000-0001-6413-329X)
- Jingwen Zhang (ORCID: https://orcid.org/0000-0003-3568-6017)
- Walter Rodríguez
- Scott A. Myers
Institutions
- University of Louisville (US)
- Norton Healthcare (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092570
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00