Hippocampal degeneration is associated with GFAP levels in individuals with vascular dementia independently of amyloidosis
Our findings suggest that astrocyte reactivity, as indicated by plasma GFAP levels, plays a significant role in the hippocampal atrophy observed in patients with vascular disease. These results suggest that therapies targeting astrocyte reactivity could potentially alleviate progressive cognitive deficits commonly found in patients with chronic vasculopathy.
Authors
- Hyun Woong Roh (ORCID: https://orcid.org/0000-0002-1333-358X)
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Joseph Therriault (ORCID: https://orcid.org/0000-0002-7826-4781)
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Cynthia Felix (ORCID: https://orcid.org/0000-0002-4283-4498)
- Guilherme Povala (ORCID: https://orcid.org/0000-0002-2023-6569)
- Douglas Teixeira Leffa (ORCID: https://orcid.org/0000-0002-4890-8451)
- Eduardo Rigon Zimmer (ORCID: https://orcid.org/0000-0002-5349-0053)
- Chang Hyung Hong (ORCID: https://orcid.org/0000-0003-3258-7611)
- Carolina Soares (ORCID: https://orcid.org/0000-0002-2338-4495)
- Sang Joon Son (ORCID: https://orcid.org/0000-0001-7434-7996)
- Guilherme Bauer‐Negrini (ORCID: https://orcid.org/0000-0003-0956-557X)
- Nesrine Rahmouni (ORCID: https://orcid.org/0009-0004-3081-8468)
- Pâmela C.L. Ferreira (ORCID: https://orcid.org/0000-0003-2134-9829)
- Emma Patrice Ruppert (ORCID: https://orcid.org/0000-0001-5877-5472)
- Andréa Lessa Benedet (ORCID: https://orcid.org/0000-0001-8219-1741)
- Matheus Scarpatto Rodrigues (ORCID: https://orcid.org/0000-0002-7794-6588)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Stijn Servaes (ORCID: https://orcid.org/0000-0003-3565-1930)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Sarah Abbas
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Cécile Tissot (ORCID: https://orcid.org/0000-0003-2711-3833)
- Hussein Zalzale
- Kaj Blennow
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Andréia Silva da Rocha (ORCID: https://orcid.org/0000-0003-1567-3374)
- Francieli Rohden (ORCID: https://orcid.org/0000-0002-9232-7371)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Pampa Saha (ORCID: https://orcid.org/0000-0002-4926-9081)
- Jenna Stevenson (ORCID: https://orcid.org/0000-0003-2848-1451)
- Vanessa Machado (ORCID: https://orcid.org/0000-0002-1243-5269)
- Markley S. Oliveira
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- University of Wisconsin–Madison (US)
- Lawrence Berkeley National Laboratory (US)
- University of Pittsburgh (US)
- McGill University Health Centre (CA)
- Instituto do Cérebro (BR)
- UK Dementia Research Institute (GB)
- University College London (GB)
- McGill University (CA)
- Ajou University (KR)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092720
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00