Aβ‐ and Tau‐Mediated Neuronal Excitability Derived from fMRI Predicts Grey Matter Atrophy in Alzheimer’s Disease
The computationally derived excitability values inversely correlated with grey matter volumes at the brain regions that most prominently showcase neurodegeneration in AD. Our results are consistent with previous observations [1,2] of increased excitability in parallel with pathological spread and the loss of neurons in the AD brain, also highlighting the fundamental role played by Aβ and tau functional interactions. References [1] Sanchez-Rodriguez et al, 2023 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370127 [2] Sanchez-Rodriguez et al, 2023 https://doi.org/10.1101/2023.09.15.557737.
Authors
- Yasser Iturria‐Medina (ORCID: https://orcid.org/0000-0002-9345-0347)
- Lazaro M. Sanchez-Rodriguez (ORCID: https://orcid.org/0000-0002-2365-8273)
- Joseph Therriault (ORCID: https://orcid.org/0000-0002-7826-4781)
- Félix Carbonell (ORCID: https://orcid.org/0000-0002-1450-0423)
- Jaime Fernández Arias (ORCID: https://orcid.org/0000-0002-6810-5920)
- Nesrine Rahmouni (ORCID: https://orcid.org/0009-0004-3081-8468)
- Stijn Servaes (ORCID: https://orcid.org/0000-0002-4431-957X)
- Cécile Tissot (ORCID: https://orcid.org/0000-0003-2711-3833)
- Gleb Bezgin (ORCID: https://orcid.org/0000-0002-1069-9201)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Jenna Stevenson (ORCID: https://orcid.org/0000-0003-2848-1451)
Institutions
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090349
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00