Hippocampal transcriptomic similarities and differences among mouse models of amyloidosis

In this study, we demonstrate that APP/PS1 and 3xTg-AD exhibit greater transcriptomic similarities between each other than with hAß-KI. Only four DEGs were consistently identified in all models. However, despite this, the three models show common alterations in 16 biological processes. These findings collectively indicate that, at the biological processes level, transgenic mouse models carrying autosomal dominant Alzheimer's disease traits and a knock-in (KI) mouse model share common pathophysiological features, being suited for translational studies.