Whole‐brain Cellome‐Wide Association Study (CWAS) Unveils Ultra‐Early Neurodegeneration Phenomena in a 3D Spatial Cell Atlas
Our findings establish the concept of "spatial cellomics" realized through spatially precise organ mapping and integrated multiomics analysis at the single-cell level. This approach shifts pathology, providing deeper insight into disease mechanisms and preventive strategies. References [1] Murakami TC, et al. Nat Neurosci. 2018;21(4):625-637. [2] Matsumoto K*, Mitani TT*, Horiguchi SA, et al*. (*equal contribution) Nat Protoc. 2019;14(12):3506-3537.
Authors
- Hiroki R. Ueda (ORCID: https://orcid.org/0000-0001-8342-9176)
- Rikuhiro G. Yamada
- Katsuhiko Matsumoto (ORCID: https://orcid.org/0000-0002-9680-8711)
- Etsuo A. Susaki (ORCID: https://orcid.org/0000-0001-5621-7311)
- Kosei Yamaura
- Tomoki T. Mitani (ORCID: https://orcid.org/0009-0007-6995-7053)
Institutions
- RIKEN Center for Biosystems Dynamics Research (JP)
- Juntendo University Hospital (JP)
- The University of Tokyo (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088470
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00