Assessing the Effect of Combined Humanization of Apolipoprotein E, Amyloid and Tau on Cognition and Alzheimer’s Disease Pathology
Results from this project provide new insights into how amyloid, ApoE, and tau conspire to trigger and accelerate disease progression. We show that amyloid interacts with both ApoE3 and ApoE4 to drive degeneration, but in that the rate of this progression is faster in the ApoE4 background. Our findings also demonstrate that cognitive deficits are detectable much earlier than expected, in putative pre-plaque stages of disease.
Authors
- Mark Longmuir
- Arash Salahinejad (ORCID: https://orcid.org/0000-0001-7644-1273)
- Suzete Maria Cerutti (ORCID: https://orcid.org/0000-0002-5246-6721)
- Scheila Schmidt
- Marco A. M. Prado (ORCID: https://orcid.org/0000-0002-3028-5778)
- Tallulah Andrews (ORCID: https://orcid.org/0000-0003-1120-2196)
- Lisa M. Saksida (ORCID: https://orcid.org/0000-0002-8416-8171)
- Taylor W. Schmitz (ORCID: https://orcid.org/0000-0003-0585-7524)
- Kate M. Onuska (ORCID: https://orcid.org/0000-0001-6150-4403)
- Beatriz Gangale Muratori
- Timothy J. Bussey (ORCID: https://orcid.org/0000-0002-3180-3709)
- Bryan Lung
- Aya Arrar
Institutions
- Western University (CA)
- Lawson Health Research Institute (CA)
- Robarts Clinical Trials (CA)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092571
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00