Preservation amidst decline: wake‐promoting histaminergic system provides a novel target to mitigate sleep/wake dysfunction in Alzheimer’s disease
Stereological data revealed that the decline in histaminergic neurons is associated with pTau accumulation and reduced histamine synthesis rather than neuronal loss. This is corroborated by a decrease in HDC expression and an upregulation of histaminergic receptor expression (potentially compensatory) in late Braak stages. Interventions focused on pTau removal may succeed in reinstating histaminergic neuro-transmission/-modulation, improving cognition, and restoring sleep-wake dysfunction in AD patients.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Renata Elaine Paraízo Leite (ORCID: https://orcid.org/0000-0002-5878-398X)
- Felipe Luiz Pereira (ORCID: https://orcid.org/0000-0001-9326-2365)
- Abhijit Satpati (ORCID: https://orcid.org/0000-0003-2674-7973)
- Roberta Diehl Rodriguez (ORCID: https://orcid.org/0000-0002-6544-7861)
- Carlos Augusto Pasqualucci (ORCID: https://orcid.org/0000-0001-6608-2473)
- Salvatore Spina (ORCID: https://orcid.org/0000-0003-3570-9143)
- Vítor Ribeiro Paes (ORCID: https://orcid.org/0000-0001-8752-5624)
- Thomas C. Neylan (ORCID: https://orcid.org/0000-0002-1572-2626)
- Cláudia Kimie Suemoto (ORCID: https://orcid.org/0000-0002-5942-4778)
- Mihovil Mladinov (ORCID: https://orcid.org/0000-0002-4886-7119)
- Alexander Soloviev (ORCID: https://orcid.org/0000-0001-6519-1547)
- William W. Seeley (ORCID: https://orcid.org/0000-0003-1410-2027)
- Christine M. Walsh
- Wilson Jacob Filho (ORCID: https://orcid.org/0000-0003-2290-4492)
Institutions
- Universidade de São Paulo (BR)
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
- Universitätsmedizin Rostock (DE)
- Klinik und Poliklinik für Psychiatrie und Psychotherapie (DE)
- Global Brain Health Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091638
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00