Genome‐wide Interaction and Stratified Study with Smoking Identifies Association of <i>APAF1</i> and <i>MIXL1/LIN9</i> with Alzheimer’s Disease

In this gene-smoking interaction and smoking-stratified GWAS of AD, we identified two promising loci. These findings highlight the strength of utilizing cross-ancestry datasets and considering both genetic and environmental factors together towards a personalized medicine approach to AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.091434
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Genome‐wide Interaction and Stratified Study with Smoking Identifies Association of APAF1 and MIXL1/LIN9 with Alzheimer’s Disease

Madeline Uretsky, Timothy J. Hohman, Adam M. Brickman, Rhoda Au et al.
Alzheimer s & Dementia
Genetic Associations and Epidemiology
article

Genome‐wide Interaction and Stratified Study with Smoking Identifies Association of APAF1 and MIXL1/LIN9 with Alzheimer’s Disease

Madeline Uretsky, Timothy J. Hohman, Adam M. Brickman, Rhoda Au, Jonathan L. Haines, Jaeyoon Chung, Lindsay A. Farrer, Michael L. Cuccaro, Paul K. Crane, Bobak Abdolmohammadi, Xudong Han, Max Rosenthaler, Walter A. Kukull, Ralph G. Dacey, Annie Lee, Shruti Durape, M. Ilyas Kamboh, Kathryn L. Lunetta, Jesse Mez, Mackenzie Moore, Margaret A. Pericak‐Vance, David A. Bennett, Gerard D. Schellenberg, Richard Mayeux
article en

Abstract

In this gene-smoking interaction and smoking-stratified GWAS of AD, we identified two promising loci. These findings highlight the strength of utilizing cross-ancestry datasets and considering both genetic and environmental factors together towards a personalized medicine approach to AD.

Alzheimer s & DementiaVol. 20(S1)
Boston University (US), Rush University Medical Center (US), University of Miami (US), University of Pittsburgh (US), University of Washington (US), Framingham Heart Study (US), Dr. John T. Macdonald Foundation (US), Case Western Reserve University (US), Columbia University (US), University of Pennsylvania (US), Vanderbilt University Medical Center (US)
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Openalex Percentile: Top 73%
Genetic Associations and Epidemiology
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