Genome‐wide Interaction and Stratified Study with Smoking Identifies Association of <i>APAF1</i> and <i>MIXL1/LIN9</i> with Alzheimer’s Disease
In this gene-smoking interaction and smoking-stratified GWAS of AD, we identified two promising loci. These findings highlight the strength of utilizing cross-ancestry datasets and considering both genetic and environmental factors together towards a personalized medicine approach to AD.
Authors
- Madeline Uretsky (ORCID: https://orcid.org/0000-0002-7604-3619)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Rhoda Au (ORCID: https://orcid.org/0000-0001-7742-4491)
- Jonathan L. Haines (ORCID: https://orcid.org/0000-0002-4351-4728)
- Jaeyoon Chung (ORCID: https://orcid.org/0000-0002-6431-9454)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Paul K. Crane (ORCID: https://orcid.org/0000-0003-4278-7465)
- Bobak Abdolmohammadi
- Xudong Han (ORCID: https://orcid.org/0000-0001-7961-5179)
- Max Rosenthaler (ORCID: https://orcid.org/0000-0002-4302-1691)
- Walter A. Kukull (ORCID: https://orcid.org/0000-0001-8761-9014)
- Ralph G. Dacey (ORCID: https://orcid.org/0000-0002-9181-6413)
- Annie Lee (ORCID: https://orcid.org/0000-0003-3726-6024)
- Shruti Durape
- M. Ilyas Kamboh (ORCID: https://orcid.org/0000-0002-3453-1438)
- Kathryn L. Lunetta (ORCID: https://orcid.org/0000-0002-9268-810X)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Mackenzie Moore
- Margaret A. Pericak‐Vance
- David A. Bennett
- Gerard D. Schellenberg
- Richard Mayeux
Institutions
- Boston University (US)
- Rush University Medical Center (US)
- University of Miami (US)
- University of Pittsburgh (US)
- University of Washington (US)
- Framingham Heart Study (US)
- Dr. John T. Macdonald Foundation (US)
- Case Western Reserve University (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091434
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00