Differential Effects of Anticholinergic Medications in Patient hiPSC‐Derived Neurons
Stem cell-derived neuronal models provide a useful strategy to complement pharmacoepidemiological studies to help distinguish molecular pathways versus confounding by indication of drugs associated with dementia risk. Preliminary results suggest that different AC medications have differential effects on AD-associated cellular outcomes that are consistent across hiPSC-Ns derived from individuals with various genetic backgrounds, indicating a molecular effect of the drug.
Authors
- Jordan Ogg
- Inez K.A. Pranoto (ORCID: https://orcid.org/0000-0002-0709-5642)
- Jessica E. Young (ORCID: https://orcid.org/0000-0003-2106-0339)
- Tiara A. Schwarze‐Taufiq
- Ruowei Zhu
- Paul K. Crane (ORCID: https://orcid.org/0000-0002-7327-3873)
- Shelly L. Gray (ORCID: https://orcid.org/0000-0001-5507-1859)
- Kathleen K.S. Hui
Institutions
- California Institute for Regenerative Medicine (US)
- University of Washington (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092559
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00