Novel mechanisms of cytosolic phospholipase A2 beta in neurodegeneration and cognitive impairments of Alzheimer’s disease
This is the first report revealing increased expression of cPLA2β in synaptosomes from brains with MCI and AD compared with controls. cPLA2β is associated with tau pathology, AA and its metabolites, synaptic and cognitive performance. Whether reducing cPLA2b reverses AD pathology merits further investigation.
Authors
- Stan G. Louie (ORCID: https://orcid.org/0000-0001-5941-6690)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Zoe Arvanitakis (ORCID: https://orcid.org/0000-0001-7477-8884)
- Bilal E. Kerman (ORCID: https://orcid.org/0000-0003-1106-3288)
- Brandon Ebright (ORCID: https://orcid.org/0000-0002-8939-6069)
- Hussein N. Yassine (ORCID: https://orcid.org/0000-0002-2483-649X)
- Antonio Sánchez (ORCID: https://orcid.org/0000-0001-7168-6175)
- Debra Hawes (ORCID: https://orcid.org/0000-0001-5936-4835)
- Kyle Hurth (ORCID: https://orcid.org/0000-0003-0115-4610)
- Daniel S. Badie
- Dante Dikeman (ORCID: https://orcid.org/0009-0002-3085-0973)
- Jing Li (ORCID: https://orcid.org/0000-0001-8331-1661)
- Shaowei Wang (ORCID: https://orcid.org/0000-0002-1267-9554)
- Boyang Li (ORCID: https://orcid.org/0000-0003-2808-9986)
- Qiu‐Lan Ma
- Jasmin Galvan
Institutions
- University of Southern California (US)
- Rush University Medical Center (US)
- LAC+USC Medical Center (US)
- Keck Hospital of USC (US)
- Rush University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092113
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00