Examining APOE4 overexpression effects in iAstrocytes across European and African ancestries
The overexpression of APOEε4 in iAstrocytes resulted in alteration in gene regulatory patterns, including the ECM and key signaling pathways across ancestries (EU and AF). In addition, gene expression differences were identified between ancestries. Further analyses of these ancestry-specific transcriptional differences may help to elucidate the mechanisms that drive the differential AD risk seen in APOEε4 individuals across ancestries.
Authors
- Juan I. Young
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Goldie S. Byrd (ORCID: https://orcid.org/0000-0003-1057-0261)
- Jeffery M. Vance (ORCID: https://orcid.org/0000-0003-3815-8199)
- Jack Trittipo (ORCID: https://orcid.org/0000-0003-1231-4691)
- Briseida E. Feliciano‐Astacio (ORCID: https://orcid.org/0000-0003-4747-8928)
- Takiyah D. Starks (ORCID: https://orcid.org/0000-0001-7267-3480)
- Heriberto Acosta
- Oded Oron (ORCID: https://orcid.org/0000-0002-2379-5008)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Larry D. Adams
- Margaret A Pericak‐Vance
Institutions
- University of Miami (US)
- Central University of the Caribbean (PR)
- Dr. John T. Macdonald Foundation (US)
- Center for Advanced Studies on Puerto Rico and the Caribbean (PR)
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092321
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00