Relationship between brain stiffness, microstructural integrity, beta‐amyloid accumulation, and cognitive decline in beta‐amyloid positive individuals
The Shapley regression analyses demonstrated that SUVR and |G*| were the most interrelated imaging covariates for multiple brain regions, which is promising for finding correlates of PET through MRE. Additionally, correlations between SUVR or |G*| and MD, but not SUVR and |G*| in the temporal cortex may be indicative of cascades which contribute to Aβ deposition, microstructural damage, and tissue softening and degradation.
Authors
- Mehmet Kurt (ORCID: https://orcid.org/0000-0002-5618-0296)
- Oleksandr Khegai
- Priti Balchandani (ORCID: https://orcid.org/0000-0001-7709-5835)
- Trey Hedden
- Mackenzie Langan (ORCID: https://orcid.org/0000-0001-7783-0414)
- Sarah Binder
- A. Dı́az (ORCID: https://orcid.org/0009-0009-2319-8842)
- Em Triolo
Institutions
- University of Washington (US)
- Mount Sinai Hospital (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091008
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00