Enhanced microglial dynamics in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer’s disease
Our findings indicate that the amyloid-plaque microenvironment in AsymAD brains is characterized by microglia with highly efficient actin-based cell motility mechanisms and decreased tau seeding versus that observed in AD brains. These two mechanisms can potentially protect against the toxic cascade initiated by Aβ, preserving brain health, and slowing AD pathology progression.
Authors
- Nur Jury (ORCID: https://orcid.org/0000-0002-1143-3595)
- Pablo Martínez (ORCID: https://orcid.org/0000-0003-3496-4652)
- Yanwen You
- Javier Redding‐Ochoa (ORCID: https://orcid.org/0000-0002-0677-917X)
- Cristian A Lasagna Reeves
- Jungsu Kim (ORCID: https://orcid.org/0000-0002-6931-8581)
- Juan C. Troncoso (ORCID: https://orcid.org/0000-0001-9553-6673)
- Hande Karahan (ORCID: https://orcid.org/0000-0003-3192-7362)
- Travis S. Johnson (ORCID: https://orcid.org/0000-0002-4628-2256)
- Jie Zhang (ORCID: https://orcid.org/0000-0001-6939-7905)
- Enrique Chimal Juarez
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091631
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00