Proteomic characterization of the TgF344 AD rat model of Alzheimer’s disease as a function of disease and therapeutic treatment
Pathway analysis of the differentially expressed proteins in AD that were normalized by P7C3 treatment were enriched in oxidative phosphorylation, glycolysis, tricarboxylic acid cycle, autophagy, tight junction, steroid and bile acid biosynthesis pathways. This provide insights into the pathophysiology of this AD model and complementary insights into future therapeutic opportunities.
Authors
- Kathryn Franke (ORCID: https://orcid.org/0000-0002-3038-2826)
- Bindu D. Paul (ORCID: https://orcid.org/0000-0002-1862-6103)
- Jaymie R. Voorhees
- Kalyani Chaubey (ORCID: https://orcid.org/0000-0002-6378-6739)
- Youngmin Yu
- Andrew A. Pieper (ORCID: https://orcid.org/0000-0001-6299-6577)
- Sarah Barker (ORCID: https://orcid.org/0000-0002-3927-6966)
- Coral J. Cintrón-Pérez (ORCID: https://orcid.org/0000-0003-2160-4244)
- Noelle Sevilir Williams (ORCID: https://orcid.org/0000-0003-1894-5742)
- Edwin Vázquez‐Rosa (ORCID: https://orcid.org/0009-0005-4508-5217)
- Xinming Wang
Institutions
- Johns Hopkins University (US)
- University Hospitals of Cleveland (US)
- Louis Stokes Cleveland VA Medical Center (US)
- Case Western Reserve University (US)
- The University of Texas Southwestern Medical Center (US)
- University of Toledo (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090366
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00