Long‐read sequencing reveals common structural variants as potential drivers of genetic rick for neurodegenerative diseases
Our findings provide the first support for SVs as candidate-drivers of the association between respective GWAS loci with AD risk. Hence, SVs may lead to increased effect sizes.
Authors
- Marc Hulsman (ORCID: https://orcid.org/0000-0002-9889-3606)
- Yaran Zhang (ORCID: https://orcid.org/0000-0003-2601-0824)
- Wiesje M. van der Flier (ORCID: https://orcid.org/0000-0001-8766-6224)
- Lydian Knoop
- Henne Holstege (ORCID: https://orcid.org/0000-0002-7688-3087)
- Marcel Reinders (ORCID: https://orcid.org/0000-0002-1148-1562)
- Sven J. van der Lee (ORCID: https://orcid.org/0000-0003-1606-8643)
- Jana Křížová (ORCID: https://orcid.org/0000-0003-1841-7341)
- Alex Salazar (ORCID: https://orcid.org/0000-0002-8453-8769)
- Sanduni Wijesekera
- Daniel Álvarez Sirvent
- Yolande A.L. Pijnenburg (ORCID: https://orcid.org/0000-0003-2464-1905)
- Niccoló Tesi (ORCID: https://orcid.org/0000-0002-1413-5091)
Institutions
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- Delft University of Technology (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092769
- Primary Topic
- Neurological diseases and metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00