Harnessing chromatin loops to identify susceptibility genes in different populations for Alzheimer’s disease: rs3851179 links to <i>PICALM</i> not <i>EED</i>
This initial application of Hi-C data demonstrates the utility of chromatin regulatory maps in nominating target genes of GWAS hits in non-coding loci. The generation and eventual application of Hi-C maps in African and Amerindian genomes (which are part of the AA or American Hispanic genomic admixture) will be key dissecting ancestry-specific genetic loci and, thereby, broadening diversity in AD research.
Authors
- Sandra Weıntraub (ORCID: https://orcid.org/0000-0003-2605-5205)
- Margaret E. Flanagan (ORCID: https://orcid.org/0009-0008-7078-3545)
- Juan I. Young
- Theresa Schuck
- Leina Lu (ORCID: https://orcid.org/0000-0001-9878-1068)
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Farid Rajabli (ORCID: https://orcid.org/0000-0001-5229-7254)
- Changiz Geula (ORCID: https://orcid.org/0000-0002-9311-3295)
- Jeffery M. Vance (ORCID: https://orcid.org/0000-0003-3815-8199)
- Katrina Celis
- Marla Gearing (ORCID: https://orcid.org/0000-0002-1959-7412)
- Margaret A. Pericak‐Vance (ORCID: https://orcid.org/0000-0001-7283-8804)
- Fulai Jin (ORCID: https://orcid.org/0000-0003-0025-4337)
- William K. Scott (ORCID: https://orcid.org/0000-0001-9336-6404)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- David A. Bennett
- Liyong Wang (ORCID: https://orcid.org/0000-0001-8299-2602)
- Wanying Xu (ORCID: https://orcid.org/0000-0002-9633-232X)
Institutions
- Northwestern University (US)
- Rush University Medical Center (US)
- University of Miami (US)
- Emory University (US)
- Dr. John T. Macdonald Foundation (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092337
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00