DNA methylation analysis from oral brushing reveals a field cancerization effect in proliferative verrucous leukoplakia
The present study provides evidence that PVL shares an aberrant methylation profile with contralateral OSCC. In agreement with the theory of field cancerization, our data point towards the potential role of epigenetics in patients at risk of developing multiple neoplastic events.
Authors
- Achille Tarsitano (ORCID: https://orcid.org/0000-0002-5815-7591)
- Roberto Rossi (ORCID: https://orcid.org/0000-0002-6228-2934)
- Giulia Querzoli (ORCID: https://orcid.org/0000-0002-6944-6508)
- Asia Sangiovanni
- Andrea Gabusi (ORCID: https://orcid.org/0000-0002-7247-8615)
- Luca Morandi (ORCID: https://orcid.org/0000-0002-3810-9760)
- Maria Pia Foschini (ORCID: https://orcid.org/0000-0001-7079-7260)
- Elisabetta Lucchi
- Davide Bartolomeo Gissi (ORCID: https://orcid.org/0000-0002-0195-7694)
- Lucio Montebugnoli
Institutions
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Azienda USL di Bologna (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Ospedale Bellaria (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Pathologica
- Published
- 2024-12-01
- DOI
- https://doi.org/10.32074/1591-951x-n838
- Citations
- 1
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.40