Toll-like receptor 4 inhibition by pyridostigmine is associated with a reduction in hypertension and inflammation in rat models of preeclampsia
Our data support that PYR attenuates placental TLR4 expression and inhibits TLR4/TRAF6/NF-κB signaling pathway-mediated inflammation in RUPP, clarifying the anti-inflammatory mechanisms of PYR in the PE rat model.
Authors
- Yuan Meng (ORCID: https://orcid.org/0000-0002-9591-0052)
- Abdoulaye Issotina Zibrila (ORCID: https://orcid.org/0009-0004-5755-0342)
- Zheng Wang (ORCID: https://orcid.org/0000-0002-0265-7546)
- Zhaoshu Zeng (ORCID: https://orcid.org/0000-0001-5094-8375)
- Ming Zeng (ORCID: https://orcid.org/0000-0001-9717-1751)
- Xiaoxu Liu (ORCID: https://orcid.org/0000-0001-9893-0510)
- Jinjun Liu (ORCID: https://orcid.org/0000-0002-4494-6602)
- Asma A Alkuhali
- Xiaomin Wang
- Md. Ahasan Ali
Institutions
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Journal of Hypertension
- Published
- 2024-11-02
- DOI
- https://doi.org/10.1097/hjh.0000000000003911
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.58