Tenofovir Induced Lichenoid Planus Drug Reaction

Antiretroviral therapy has significantly transformed the progression of HIV and improved the quality of life for individuals living with HIV. However, many drug treatments can have lasting side effects, one of which is a lichenoid drug reaction (DLR). Here, we present the case of a 55-year-old female on tenofovir therapy for HIV, who developed lichen planus lesions. Tenofovir was discontinued and topical treatment with clobetasol 0.05% and hydroxyzine 10mg resulted in significant improvement and resolution of the lesions. Extended follow-up proved beneficial in managing this patient, with eventual resolution and no recurrence of the lesions.