Comparing driving behaviors and physiological features of older adult drivers with and without elevated amyloid burden

Cognitively normal amyloid positive older drivers demonstrated consistently higher HR and lower EDA in key driving situations compared to their amyloid negative peers. Findings suggest physiological responses of older drivers under different driving conditions may represent markers for identifying those individuals at higher risk of future cognitive decline. These results can be used to build an accurate and generalizable Machine Learning-based AD diagnostic tool to detect early-stage AD in drivers.