Effects of BDNF and COMT variants on cognitive decline in Early‐Onset Alzheimer’s Disease
Results suggest subtle effects of BDNF p.V66M carrier status on memory decline in EOAD participants, which was not observed for disease progression/age-of-onset. No effects for COMT p.V158M carrier status were observed. Future investigation will replicate these effects in larger samples, permitting stratification of additional covariates including APOE genotype.
Authors
- María C. Carrillo (ORCID: https://orcid.org/0000-0003-3057-2387)
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Gil D. Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Dustin B. Hammers (ORCID: https://orcid.org/0000-0002-1644-2618)
- Kelly Nudelman (ORCID: https://orcid.org/0000-0003-4040-1717)
- Ani Eloyan (ORCID: https://orcid.org/0000-0002-8110-7680)
- Bradford C. Dickerson (ORCID: https://orcid.org/0000-0002-5958-3445)
- Hee Jin Kim (ORCID: https://orcid.org/0000-0002-3186-9441)
- Tatiana M. Foroud
- Liana G. Apostolova
- Jane Musema
Institutions
- Alzheimer's Association (US)
- Harvard University (US)
- University of California, San Francisco (US)
- Brown University (US)
- Samsung Medical Center (KR)
- Massachusetts General Hospital (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092383
- Citations
- 1
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.34