Long‐read transcript sequencing identifies differential isoform expression in the entorhinal cortex in a transgenic model of tau pathology
Our results highlight the importance of differential transcript usage, even in the absence of gene-level expression alterations, as a mechanism underpinning gene regulation in the development of neuropathology. Our transcript annotations and a novel informatics pipeline for the analysis of long-read transcript sequencing data are provided as a resource to the community.
Authors
- Szi Kay Leung (ORCID: https://orcid.org/0000-0002-5607-4688)
- Eilis J. Hannon (ORCID: https://orcid.org/0000-0001-6840-072X)
- Rosemary A. Bamford (ORCID: https://orcid.org/0000-0002-2107-4637)
- Isabel Castanho (ORCID: https://orcid.org/0000-0003-1413-626X)
- Jonathan S. Mill (ORCID: https://orcid.org/0000-0003-1115-3224)
- Aaron R. Jeffries (ORCID: https://orcid.org/0000-0002-1235-8291)
- Emma Louise Dempster (ORCID: https://orcid.org/0000-0003-1257-5314)
- Zeshan Ahmed
Institutions
- University of Exeter (GB)
- Harvard University Press (US)
- Eli Lilly (United Kingdom) (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089436
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00