Sex Differences in Neuropsychiatric Symptoms Associated with Alzheimer’s Disease in Down Syndrome
AD appears to affect men and women differently after the transition to dementia. Affected males engage in fewer activities and are less interested in their surroundings than females, suggesting greater apathy or withdrawal, despite the lack of sex differences in depressive symptomology during the preclinical and clinical stages of AD. Possible neurobiological reasons will be discussed as well as how individuals with DS and AD may need tailored support based on sex differences in psychiatric and behavioral symptoms.
Authors
- Margaret B. Pulsifer (ORCID: https://orcid.org/0000-0003-3160-4846)
- Sharon J. Krinsky‐McHale (ORCID: https://orcid.org/0000-0002-7205-7319)
- Wayne Silverman (ORCID: https://orcid.org/0000-0002-7842-8600)
- Christy Hom (ORCID: https://orcid.org/0000-0003-0266-0961)
- Florence Lai (ORCID: https://orcid.org/0000-0003-4354-0624)
- Ira T. Lott (ORCID: https://orcid.org/0000-0002-3107-0752)
- H. Diana Rosas
- Sophia E. Shaka (ORCID: https://orcid.org/0000-0002-4441-9773)
Institutions
- Harvard University (US)
- University of California, Irvine (US)
- New York State Office for People With Developmental Disabilities (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091071
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00